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Details on Person AKT1 E17K mutant translocates to the nucleus

Class:Id	Reaction:2399997
_displayName	AKT1 E17K mutant translocates to the nucleus
_doRelease	TRUE
_timestamp	2015-08-05 19:39:31
authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:2399987] Orlic-Milacic, M, 2012-07-13
disease	[Disease:1500689] cancer
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
entityFunctionalStatus	[EntityFunctionalStatus:2400002] gain_of_function of p-T308,S473-AKT1 E17K [cytosol]
input	[EntityWithAccessionedSequence:2243935] p-T308,S473-AKT1 E17K [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:199341] Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve growth factor stimulation and associates with the nuclear matrix protein nucleolin
modified	[InstanceEdit:2404247] Orlic-Milacic, M, 2012-07-16 [InstanceEdit:2428913] Orlic-Milacic, M, 2012-08-08 [InstanceEdit:2457739] Orlic-Milacic, M, 2012-08-28 [InstanceEdit:2463861] Orlic-Milacic, M, 2012-08-30 [InstanceEdit:3080552] Orlic-Milacic, M, 2013-02-07 [InstanceEdit:6789900] Orlic-Milacic, Marija, 2015-08-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AKT1 E17K mutant translocates to the nucleus
normalReaction	[Reaction:198298] AKT translocates to the nucleus [Homo sapiens]
output	[EntityWithAccessionedSequence:2399994] p-T308,S473-AKT1 E17K [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2243942] PDPK1 phosphorylates AKT1 E17K mutant [Homo sapiens] [Reaction:2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 [Homo sapiens]
releaseDate	2012-09-18
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464963] R-HSA-2399997.3
summation	[Summation:2399986] AKT1 E17K gain-of-function mutant is expected to translocate...
(hasEvent)	[Pathway:3080609] Constitutive Signaling by AKT1 E17K Mutant in Cancer [Homo sapiens] [Pathway:5674400] Constitutive Signaling by AKT1 E17K in Cancer [Homo sapiens]
(precedingEvent)	[Reaction:2399988] AKT1 E17K mutant phosphorylates NR4A1 (NUR77) [Homo sapiens] [Reaction:2399992] AKT1 E17K mutant phosphorylates forkhead box transcription factors [Homo sapiens] [Reaction:2399996] AKT1 E17K mutant phosphorylates CREB1 [Homo sapiens] [Reaction:2399999] AKT1 E17K mutant phosphorylates RSK [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784072] Update Tracker - [Reaction:2399997] AKT1 E17K mutant translocates to the nucleus - v54:[addLiteratureReference]
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