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Details on Person AKT1 E17K mutant phosphorylates forkhead box transcription factors

Class:IdReaction:2399992
_displayNameAKT1 E17K mutant phosphorylates forkhead box transcription factors
_doReleaseTRUE
_timestamp2018-08-10 13:37:26
authored[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
catalystActivity[CatalystActivity:2399993] protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:2399987] Orlic-Milacic, M, 2012-07-13
disease[Disease:1500689] cancer
edited[InstanceEdit:2426555] Matthews, L, 2012-08-03
entityFunctionalStatus[EntityFunctionalStatus:2400003] gain_of_function of p-T308,S473-AKT1 E17K [nucleoplasm]
input[CandidateSet:199272] FOXO1,FOXO3,FOXO4,(FOXO6) [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
literatureReference[LiteratureReference:1500571] A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
[LiteratureReference:199294] Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
[LiteratureReference:199277] Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
[LiteratureReference:199313] Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family
modified[InstanceEdit:2404247] Orlic-Milacic, M, 2012-07-16
[InstanceEdit:2428913] Orlic-Milacic, M, 2012-08-08
[InstanceEdit:2457737] Orlic-Milacic, M, 2012-08-28
[InstanceEdit:2463861] Orlic-Milacic, M, 2012-08-30
[InstanceEdit:3080552] Orlic-Milacic, M, 2013-02-07
[InstanceEdit:9616342] Orlic-Milacic, Marija, 2018-08-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAKT1 E17K mutant phosphorylates forkhead box transcription factors
normalReaction
output[CandidateSet:9614997] p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6) [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent
releaseDate2012-09-18
reviewed[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13
[InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13
[InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2464959] R-HSA-2399992.3
summation[Summation:2400000] AKT1 E17K gain-of-function mutant phosphorylates FOXO3 (Carp...
(hasEvent)[Pathway:3080609] Constitutive Signaling by AKT1 E17K Mutant in Cancer [Homo sapiens]
[Pathway:5674400] Constitutive Signaling by AKT1 E17K in Cancer [Homo sapiens]
(updatedInstance)[_UpdateTracker:9779105] Update Tracker - [Reaction:2399992] AKT1 E17K mutant phosphorylates forkhead box transcription factors - v66:[add_removeOutput, modifyText]
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No pathways have been reviewed or authored by AKT1 E17K mutant phosphorylates forkhead box transcription factors (2399992)
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