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Details on Person AKT1 E17K mutant phosphorylates caspase-9

Class:Id	Reaction:2399985
_displayName	AKT1 E17K mutant phosphorylates caspase-9
_doRelease	TRUE
_timestamp	2022-02-07 19:19:41
authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
catalystActivity	[CatalystActivity:2399974] protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2399987] Orlic-Milacic, M, 2012-07-13
disease	[Disease:1500689] cancer
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
entityFunctionalStatus	[EntityFunctionalStatus:2400002] gain_of_function of p-T308,S473-AKT1 E17K [cytosol]
input	[SimpleEntity:113592] ATP [cytosol] [EntityWithAccessionedSequence:57033] CASP9(1-416) [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:199348] Regulation of cell death protease caspase-9 by phosphorylation
modified	[InstanceEdit:2404247] Orlic-Milacic, M, 2012-07-16 [InstanceEdit:2428913] Orlic-Milacic, M, 2012-08-08 [InstanceEdit:2457736] Orlic-Milacic, M, 2012-08-28 [InstanceEdit:2463861] Orlic-Milacic, M, 2012-08-30 [InstanceEdit:3080552] Orlic-Milacic, M, 2013-02-07 [InstanceEdit:9763925] D'Eustachio, Peter, 2022-02-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AKT1 E17K mutant phosphorylates caspase-9
normalReaction	[Reaction:198621] AKT phosphorylates caspase-9 [Homo sapiens]
output	[SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:198636] p-S196-CASP9(1-416) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:2243942] PDPK1 phosphorylates AKT1 E17K mutant [Homo sapiens] [Reaction:2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 [Homo sapiens]
releaseDate	2012-09-18
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464906] R-HSA-2399985.3
summation	[Summation:2399991] AKT1 E17K gain-of-function mutant is expected to phosphoryla...
(hasEvent)	[Pathway:3080609] Constitutive Signaling by AKT1 E17K Mutant in Cancer [Homo sapiens] [Pathway:5674400] Constitutive Signaling by AKT1 E17K in Cancer [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775194] Update Tracker - [Reaction:2399985] AKT1 E17K mutant phosphorylates caspase-9 - v80:[add_removeInput]
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No pathways have been reviewed or authored by AKT1 E17K mutant phosphorylates caspase-9 (2399985)