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Details on Person AKT1 E17K gain-of-function mutant is expected to phosphoryla...
| Class:Id | Summation:2399983 |
|---|---|
| _displayName | AKT1 E17K gain-of-function mutant is expected to phosphoryla... |
| _timestamp | 2012-07-13 15:11:09 |
| created | [InstanceEdit:2399979] Orlic-Milacic, M, 2012-07-13 |
| literatureReference | [LiteratureReference:199351] HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation [LiteratureReference:2399962] Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation [LiteratureReference:2399963] A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein |
| text | AKT1 E17K gain-of-function mutant is expected to phosphorylate MDM2, like the wild-type AKT (Zhou et al. 2001, Feng et al. 2004, Milne et al. 2004), but this has not been experimentally tested. |
| (summation) | [Reaction:2399981] AKT1 E17K mutant phosphorylates MDM2 [Homo sapiens] |
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No pathways have been reviewed or authored by AKT1 E17K gain-of-function mutant is expected to phosphoryla... (2399983)
