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Details on Person The inframe deletion of amino acid residues at position 463 ...

Class:IdSummation:2399696
_displayNameThe inframe deletion of amino acid residues at position 463 ...
_timestamp2012-07-12 16:15:45
created[InstanceEdit:2399709] Orlic-Milacic, M, 2012-07-12
literatureReference[LiteratureReference:2399690] PIK3R1 (p85?) is somatically mutated at high frequency in primary endometrial cancer
textThe inframe deletion of amino acid residues at position 463 to 466 in the iSH2 domain of PIK3R1 relieves inhibition of PI3K catalytic subunit PIK3CA and enables constitutive activity of PI3K complex that contains PIK3R1 Y463_L466del mutant (Urick et al. 2011).
(summation)[EntityWithAccessionedSequence:2399546] PIK3R1 Y463_L466del [plasma membrane] [Homo sapiens]
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