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Details on Person Substitution of methionine residue with valine at position 1...

Class:IdSummation:2399641
_displayNameSubstitution of methionine residue with valine at position 1...
_timestamp2012-07-11 19:39:24
created[InstanceEdit:2399638] Orlic-Milacic, M, 2012-07-11
literatureReference[LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
textSubstitution of methionine residue with valine at position 1043 in the kinase domain of PIK3CA is predicted, based on PIK3CA crystal structure, to change the conformation of the activation loop (Huang et al. 2007).
(summation)[EntityWithAccessionedSequence:2395932] PIK3CA M1043V [cytosol] [Homo sapiens]
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