Query author contributions in Reactome
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Details on Person Based on structural and functional studies of PIK3CA Q546K m...
| Class:Id | Summation:2399611 |
|---|---|
| _displayName | Based on structural and functional studies of PIK3CA Q546K m... |
| _timestamp | 2012-07-11 17:21:40 |
| created | [InstanceEdit:2399619] Orlic-Milacic, M, 2012-07-11 |
| literatureReference | [LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit |
| text | Based on structural and functional studies of PIK3CA Q546K mutant (Miled et al. 2007), substitution of glutamine residue at position 546 of PIK3CA with histidine is expected to disrupt inhibitory interaction between the helical domain of PIK3CA and the nSH2 domain of PIK3R1, resulting in constitutive activity of the PI3K complex containing PIK3CA Q546H mutant. |
| (summation) | [EntityWithAccessionedSequence:2362374] PIK3CA Q546H [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by Based on structural and functional studies of PIK3CA Q546K m... (2399611)
