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Details on Person Based on structural and functional studies of the PIK3CA E54...

Class:Id	Summation:2399602
_displayName	Based on structural and functional studies of the PIK3CA E54...
_timestamp	2012-07-11 15:27:43
created	[InstanceEdit:2399582] Orlic-Milacic, M, 2012-07-11
literatureReference	[LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit [LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations [LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
text	Based on structural and functional studies of the PIK3CA E545K mutant (Miled et al. 2007, Huang et al. 2007, Zhao et al. 2005), the substitution of glutamic acid residue at position 545 of PIK3CA with valine is expected to disrupt inhibitory interaction between the helical domain of PIK3CA and the nSH2 domain of PIK3R1 and result in the constitutive activity of the PI3K complex containing PIK3CA E545V mutant.
(summation)	[EntityWithAccessionedSequence:2362365] PIK3CA E545V [cytosol] [Homo sapiens]
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