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Details on Person Similar to PIK3CA E545K mutant (Miled et al. 2007, Huang et ...

Class:IdSummation:2399599
_displayNameSimilar to PIK3CA E545K mutant (Miled et al. 2007, Huang et ...
_timestamp2012-07-11 17:22:45
created[InstanceEdit:2399582] Orlic-Milacic, M, 2012-07-11
literatureReference[LiteratureReference:2399617] Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells
[LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
[LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
[LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
modified[InstanceEdit:2399629] Orlic-Milacic, M, 2012-07-11
textSimilar to PIK3CA E545K mutant (Miled et al. 2007, Huang et al. 2007, Zhao et al. 2005), PIK3CA E545A mutant is constitutively active in the absence of growth factors (Horn et al. 2008). The underlying mechanism for oncogenic activation is likely to be identical - the substitution of glutamic acid residue at position 545 of PIK3CA with alanine is expected to disrupt inhibitory interaction between the helical domain of PIK3CA and the nSH2 domain of PIK3R1.
(summation)[EntityWithAccessionedSequence:2362355] PIK3CA E545A [cytosol] [Homo sapiens]
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