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Details on Person UniProt:Q9NQR4 NIT2
| Class:Id | ReferenceGeneProduct:239665 |
|---|---|
| _chainChangeLog | chain:1-276 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NQR4 NIT2 |
| _timestamp | 2025-02-21 19:40:46 |
| chain | chain:1-276 |
| checksum | 32FA797601A419C6 |
| comment | FUNCTION Has omega-amidase activity (PubMed:19595734, PubMed:22674578). The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19595734).CATALYTIC ACTIVITY a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH4(+)CATALYTIC ACTIVITY 2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+)CATALYTIC ACTIVITY 2-oxosuccinamate + H2O = oxaloacetate + NH4(+)BIOPHYSICOCHEMICAL PROPERTIES In solution, 2-oxoglutaramate is in equilibrium with a cyclic form (2-hydroxy-5-oxoproline), and at pH 8.0 or above, the rate of ring opening is no longer limiting for the omega-amidase reaction (PubMed:19595734, PubMed:22674578). The kinetic constants are determined for the recombinant His6-tagged protein (PubMed:22674578).SUBUNIT Homodimer.SUBCELLULAR LOCATION Detected in fetal brain (at protein level). Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, prostate, spleen, thymus, prostate, testis, ovary, small intestine and colon.MASS SPECTROMETRY Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Omega-amidase NIT2 ecNumber evidence="6 7"3.5.1.3 alternativeName: Nitrilase homolog 2 |
| geneName | NIT2 CUA002 |
| identifier | Q9NQR4 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cytoplasm Hydrolase Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | NIT2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989662] ENSEMBL:ENSG00000114021 NIT2 [Homo sapiens] |
| secondaryIdentifier | NIT2_HUMAN B2R9A3 D3DN47 Q8WUF0 |
| sequenceLength | 276 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:6799636] NIT2 [specific granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6800935] NIT2 [tertiary granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6806297] NIT2 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9NQR4 NIT2 (239665)
