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Details on Person Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT

Class:Id	Reaction:2396606
_displayName	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
_doRelease	TRUE
_timestamp	2017-11-29 21:34:23
authored	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2396559] Garapati, P V, 2012-07-09
edited	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
input	[Complex:2424464] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] [Homo sapiens] [DefinedSet:1169089] PLC gamma1,2 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:202315] Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. [LiteratureReference:202293] Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT [LiteratureReference:2396593] TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1 [LiteratureReference:2685365] Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R
modified	[InstanceEdit:2424475] Garapati, P V, 2012-07-23 [InstanceEdit:2428958] Garapati, P V, 2012-08-09 [InstanceEdit:2730898] Garapati, P V, 2012-12-05 [InstanceEdit:2871845] Garapati, P V, 2012-12-21 [InstanceEdit:9031492] Orlic-Milacic, Marija, 2017-11-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
output	[Complex:2396571] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:2396561] Recruitment of GADS:SLP-76 to p-5Y-LAT [Homo sapiens] [Reaction:2396599] Recruitment of GRB2:SOS to p-5Y-LAT [Homo sapiens]
releaseDate	2012-09-18
reviewed	[InstanceEdit:2428957] Lanier, Lewis L, 2012-08-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464949] R-HSA-2396606.3
summation	[Summation:2396580] The phospholipase PLC-gamma is an important mediator of TCR,...
(hasEvent)	[Pathway:2424491] DAP12 signaling [Homo sapiens] [Pathway:2871796] FCERI mediated MAPK activation [Homo sapiens]
(precedingEvent)	[Reaction:2396594] Phosphorylation of SLP-76 by p-SYK [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787528] Update Tracker - [Reaction:2396606] Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT - v44:[addLiteratureReference, add_removeInput, modifyText]
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