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Details on Person Recruitment of GRB2:SOS to p-5Y-LAT

Class:Id	Reaction:2396599
_displayName	Recruitment of GRB2:SOS to p-5Y-LAT
_doRelease	TRUE
_timestamp	2017-11-30 16:11:58
authored	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2396559] Garapati, P V, 2012-07-09
edited	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
input	[EntityWithAccessionedSequence:2396597] p-5Y-LAT-2 [plasma membrane] [Homo sapiens] [Complex:2685672] p-SHC1:GRB2:SOS [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:202315] Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. [LiteratureReference:2685288] Syk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2
modified	[InstanceEdit:2424475] Garapati, P V, 2012-07-23 [InstanceEdit:2428958] Garapati, P V, 2012-08-09 [InstanceEdit:2730898] Garapati, P V, 2012-12-05 [InstanceEdit:2871845] Garapati, P V, 2012-12-21 [InstanceEdit:9031543] Orlic-Milacic, Marija, 2017-11-30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment of GRB2:SOS to p-5Y-LAT
output	[Complex:2424468] p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:2730844] Interaction of GRB2:SOS complex with p-SHC1 [Homo sapiens] [Reaction:2730886] Phosphorylation of SHC by SYK kinase [Homo sapiens] [Reaction:2395801] Phosphorylation of LAT by p-SYK [Homo sapiens] [Reaction:2395412] Phosphorylation of SYK [Homo sapiens]
releaseDate	2012-09-18
reviewed	[InstanceEdit:2428957] Lanier, Lewis L, 2012-08-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464849] R-HSA-2396599.3
summation	[Summation:2396536] GRB2 is an adapter protein that contains a central SH2 domai...
(hasEvent)	[Pathway:2424491] DAP12 signaling [Homo sapiens] [Pathway:2871796] FCERI mediated MAPK activation [Homo sapiens]
(precedingEvent)	[Reaction:2396561] Recruitment of GADS:SLP-76 to p-5Y-LAT [Homo sapiens] [Reaction:2424477] SOS mediated nucleotide exchange of RAS (SHC) [Homo sapiens] [Reaction:5672965] RAS GEFs promote RAS nucleotide exchange [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787641] Update Tracker - [Reaction:2396599] Recruitment of GRB2:SOS to p-5Y-LAT - v44:[addLiteratureReference, add_removeInput]
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