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Details on Person Phosphorylation of SLP-76 by p-SYK

Class:Id	Reaction:2396594
_displayName	Phosphorylation of SLP-76 by p-SYK
_doRelease	TRUE
_timestamp	2017-11-29 21:34:19
authored	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
catalystActivity	[CatalystActivity:2396614] protein tyrosine kinase activity of DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2396559] Garapati, P V, 2012-07-09
edited	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:2396571] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:429454] Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets [LiteratureReference:435419] SLP-76 couples Syk to the osteoclast cytoskeleton [LiteratureReference:481047] Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function
modified	[InstanceEdit:2424475] Garapati, P V, 2012-07-23 [InstanceEdit:2428958] Garapati, P V, 2012-08-09 [InstanceEdit:2730898] Garapati, P V, 2012-12-05 [InstanceEdit:9031492] Orlic-Milacic, Marija, 2017-11-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of SLP-76 by p-SYK
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:2424460] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:2396606] Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT [Homo sapiens] [Reaction:2396561] Recruitment of GADS:SLP-76 to p-5Y-LAT [Homo sapiens] [Reaction:2395412] Phosphorylation of SYK [Homo sapiens] [Reaction:210289] Recruitment of SYK to p-DAP12 [Homo sapiens]
releaseDate	2012-09-18
reviewed	[InstanceEdit:2428957] Lanier, Lewis L, 2012-08-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464868] R-HSA-2396594.3
summation	[Summation:2424328] SLP-76 lacks intrinsic catalytic activity and acts as a scaf...
(hasEvent)	[Pathway:2424491] DAP12 signaling [Homo sapiens]
(precedingEvent)	[Reaction:2424481] Recruitment of VAV and BTK to p-SLP-76 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787587] Update Tracker - [Reaction:2396594] Phosphorylation of SLP-76 by p-SYK - v44:[add_removeInput, modifyText]
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