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Details on Person Sulfated glycolipids (SGs) such as the sulfatides bind stron...

Class:IdSummation:2396442
_displayNameSulfated glycolipids (SGs) such as the sulfatides bind stron...
_timestamp2013-07-31 15:05:18
created[InstanceEdit:2396250] Jupe, S, 2012-07-09
literatureReference[LiteratureReference:2465903] Laminin binds specifically to sulfated glycolipids
[LiteratureReference:2465836] Comparison of the specificities of laminin, thrombospondin, and von Willebrand factor for binding to sulfated glycolipids
[LiteratureReference:2465895] Chemistry and functional distribution of sulfoglycolipids
[LiteratureReference:2465891] 04 and A007-sulfatide antibodies bind to embryonic Schwann cells prior to the appearance of galactocerebroside; regulation of the antigen by axon-Schwann cell signals and cyclic AMP
[LiteratureReference:2396028] Laminin-sulfatide binding initiates basement membrane assembly and enables receptor signaling in Schwann cells and fibroblasts
[LiteratureReference:1592404] Developmental and pathogenic mechanisms of basement membrane assembly
modified[InstanceEdit:2447197] Jupe, S, 2012-08-13
[InstanceEdit:2465853] Jupe, S, 2012-09-04
[InstanceEdit:4084738] Jupe, S, 2013-07-31
textSulfated glycolipids (SGs) such as the sulfatides bind strongly to the LG domains of laminin (Roberts et al. 1985, 1986, Ishizuka 1997). The most common SG, HSO3-3galactosylBeta-1ceramide (galactosyl-3-sulfate ceramide or sulfatide) is highly expressed in developing and adult peripheral nerves (Mirsky et al. 1990), Schwann cells, kidney and other tissues. SGs are thought to mediate or enhance the cell surface anchorage of laminins, possibly by allowing the short arms to bind the cell surface in addition to the LG domains (Li et al. 2005, Yurchenko & Patton 2009).
(summation)[Reaction:2396083] Laminins bind galactosyl sulfatide and related sulfated glycolipids [Homo sapiens]
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