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Details on Person Perlecan (HSPG2) is a modular proteoglycan primarily located...
| Class:Id | Summation:2396299 |
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| _displayName | Perlecan (HSPG2) is a modular proteoglycan primarily located... |
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| _timestamp | 2013-05-22 14:37:33 |
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| created | [InstanceEdit:2396250] Jupe, S, 2012-07-09 |
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| literatureReference | [Book:2327722] 9780824746520 Proteoglycans structure, biology, and molecular interactions Heparan sulfate proteoglycans in basement membranes Iozzo, Renato
[LiteratureReference:2327822] Self-assembly of a high molecular weight basement membrane heparan sulfate proteoglycan into dimers and oligomers
[LiteratureReference:3597695] Diverse cell signaling events modulated by perlecan
[URL:3597694] http://matrixdb.ibcp.fr/cgi-bin/model/report/default?name=P98160&class=BioMolecule
[LiteratureReference:2328131] Specific binding of basic fibroblast growth factor to basement membrane-like structures and to purified heparan sulfate proteoglycan of the EHS tumor
[LiteratureReference:2328157] Not all perlecans are created equal: interactions with fibroblast growth factor (FGF) 2 and FGF receptors
[LiteratureReference:2327728] Basement-membrane heparan sulfate proteoglycan binds to laminin by its heparan sulfate chains and to nidogen by sites in the protein core
[LiteratureReference:2327826] Isolation and characterization of fibronectin-binding proteoglycan carrying both heparan sulfate and dermatan sulfate chains from human placenta
[LiteratureReference:2327694] The core protein of the matrix-associated heparan sulfate proteoglycan binds to fibronectin
[LiteratureReference:2327758] Extracellular sequestration and release of fibroblast growth factor: a regulatory mechanism?
[LiteratureReference:2327900] Binding of perlecan to transthyretin in vitro
[LiteratureReference:2327934] Mapping of the binding of platelet-derived growth factor to distinct domains of the basement membrane proteins BM-40 and perlecan and distinction from the BM-40 collagen-binding epitope |
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| modified | [InstanceEdit:2426268] Jupe, S, 2012-07-31
[InstanceEdit:2426542] Jupe, S, 2012-08-03
[InstanceEdit:2426629] Jupe, S, 2012-08-08
[InstanceEdit:2867920] Jupe, S, 2012-12-19
[InstanceEdit:3597687] Jupe, S, 2013-05-22 |
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| text | Perlecan (HSPG2) is a modular proteoglycan primarily located in the basement membranes of vascular tissues. It is involved in several developmental processes, both during embryogenesis and in human diseases such as cancer and diabetes (Iozzo et al. 1994). HSPG2 can self-aggregate into dimeric or multimeric forms (Yurchenco et al. 1987) and is involved in heterotypic interactions with numerous extracellular macromolecules (Whitelock et al. 2008, Perlecan entry in MatrixDB). HSPG2's GAG chains mediate interactions with fibroblast growth factor-2 (Vigny et al. 1988, Knox et al. 2002), and nidogens (Entactins, represented elsewhere). The core protein binds fibronectin (Isemura et al. 1987, Heremans et al. 1990, Vlodavsky et al. 1991), transthyretin (Smeland et al. 1997) and platelet-derived growth factor A and B homodimers (Göhring et al. 1998). |
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| (summation) | [Reaction:2396337] HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [Homo sapiens] |
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