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Details on Person NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP

Class:Id	Reaction:2395872
_displayName	NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP
_doRelease	TRUE
_timestamp	2025-12-10 22:49:49
authored	[InstanceEdit:2395962] D'Eustachio, P, 2012-07-06
catalystActivity	[CatalystActivity:2395832] 2-hydroxy-ATP hydrolase activity of NUDT1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643728] 2-hydroxy-ATP hydrolase activity of NUDT1 [cytosol] The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2395885] D'Eustachio, P, 2012-07-03
crossReference	[DatabaseIdentifier:9976352] RHEA:67393
edited	[InstanceEdit:2395962] D'Eustachio, P, 2012-07-06
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:9731240] 2-oxo-ATP(4-) [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2395886] Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP [LiteratureReference:1418849] Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria [LiteratureReference:2395806] Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates
modified	[InstanceEdit:2395889] D'Eustachio, P, 2012-07-03 [InstanceEdit:2395960] D'Eustachio, P, 2012-07-06 [InstanceEdit:2399542] D'Eustachio, P, 2012-07-10 [InstanceEdit:2509808] D'Eustachio, P, 2012-10-05 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9728901] D'Eustachio, Peter, 2021-04-22 [InstanceEdit:9731176] D'Eustachio, Peter, 2021-05-13 [InstanceEdit:9731239] D'Eustachio, Peter, 2021-05-18 [InstanceEdit:9731341] D'Eustachio, Peter, 2021-05-19 [InstanceEdit:9731343] D'Eustachio, Peter, 2021-05-19 [InstanceEdit:9748645] D'Eustachio, Peter, 2021-07-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10
name	NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP 2-oxo-ATP + H2O => 2-oxo-AMP + diphosphate + H(+)
output	[SimpleEntity:9731231] 2-oxo-AMP(2-) [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:111294] PPi [cytosol]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2509804] Ito, Riyoko, 2012-10-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200341] R-HSA-2395872.7
summation	[Summation:2395871] NUDT1 (MTH1) catalyzes the reaction of 2-oxo-ATP and water t...
(hasEvent)	[Pathway:2393930] Phosphate bond hydrolysis by NUDT proteins [Homo sapiens]
(precedingEvent)	[Reaction:71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775958] Update Tracker - [Reaction:2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - v78:[add_removeInput, add_removeOutput, modifyText] [_UpdateTracker:9776087] Update Tracker - [Reaction:2395872] NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP - v77:[modifyText]
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