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Details on Person NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP

Class:Id	Reaction:2395869
_displayName	NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP
_doRelease	TRUE
_timestamp	2025-12-10 22:49:55
authored	[InstanceEdit:2395962] D'Eustachio, P, 2012-07-06
catalystActivity	[CatalystActivity:2395882] 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity of NUDT15 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643300] 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity of NUDT15 [cytosol] Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2395885] D'Eustachio, P, 2012-07-03
crossReference	[DatabaseIdentifier:9976353] RHEA:31576
edited	[InstanceEdit:2395962] D'Eustachio, P, 2012-07-06
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:9731302] 8-oxo-dGTP(4-) [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2394016] Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides [LiteratureReference:2394017] Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2
modified	[InstanceEdit:2395889] D'Eustachio, P, 2012-07-03 [InstanceEdit:2395960] D'Eustachio, P, 2012-07-06 [InstanceEdit:2399542] D'Eustachio, P, 2012-07-10 [InstanceEdit:2509808] D'Eustachio, P, 2012-10-05 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9731253] D'Eustachio, Peter, 2021-05-18 [InstanceEdit:9731312] D'Eustachio, Peter, 2021-05-19 [InstanceEdit:9731341] D'Eustachio, Peter, 2021-05-19 [InstanceEdit:9731343] D'Eustachio, Peter, 2021-05-19 [InstanceEdit:9748645] D'Eustachio, Peter, 2021-07-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10
name	NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP 8-oxo-dGTP + H2O => 8-oxo-dGMP + diphosphate + H(+)
output	[SimpleEntity:9731296] 8-oxo-dGMP(2-) [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:111294] PPi [cytosol]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2509804] Ito, Riyoko, 2012-10-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200369] R-HSA-2395869.6
summation	[Summation:2395874] NUDT15 (MTH2) catalyzes the reaction of 8-oxo-dGTP and water...
(hasEvent)	[Pathway:2393930] Phosphate bond hydrolysis by NUDT proteins [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776073] Update Tracker - [Reaction:2395869] NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP - v78:[add_removeInput, add_removeOutput]
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