Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP

Class:Id	Reaction:2395849
_displayName	NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP
_doRelease	TRUE
_timestamp	2025-12-10 22:49:51
authored	[InstanceEdit:2395962] D'Eustachio, P, 2012-07-06
catalystActivity	[CatalystActivity:2395845] 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity of NUDT1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643199] 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity of NUDT1 [cytosol] Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2395811] D'Eustachio, P, 2012-07-02
crossReference	[DatabaseIdentifier:9976353] RHEA:31576
edited	[InstanceEdit:2395962] D'Eustachio, P, 2012-07-06
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:9731302] 8-oxo-dGTP(4-) [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1418849] Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria [LiteratureReference:2395806] Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates [LiteratureReference:2395856] Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism [LiteratureReference:2395831] Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis [LiteratureReference:2394017] Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2 [LiteratureReference:2395820] An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress
modified	[InstanceEdit:2395857] D'Eustachio, P, 2012-07-02 [InstanceEdit:2395885] D'Eustachio, P, 2012-07-03 [InstanceEdit:2395960] D'Eustachio, P, 2012-07-06 [InstanceEdit:2399542] D'Eustachio, P, 2012-07-10 [InstanceEdit:2509808] D'Eustachio, P, 2012-10-05 [InstanceEdit:5362692] D'Eustachio, Peter, 2014-04-16 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9731253] D'Eustachio, Peter, 2021-05-18 [InstanceEdit:9731295] D'Eustachio, Peter, 2021-05-19 [InstanceEdit:9731341] D'Eustachio, Peter, 2021-05-19 [InstanceEdit:9731343] D'Eustachio, Peter, 2021-05-19 [InstanceEdit:9748645] D'Eustachio, Peter, 2021-07-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10
name	NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP 8-oxo-dGTP + H2O => 8-oxo-dGMP + diphosphate + H(+)
output	[SimpleEntity:9731296] 8-oxo-dGMP(2-) [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:111294] PPi [cytosol]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2509804] Ito, Riyoko, 2012-10-05
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5362673] D'Eustachio, Peter, 2014-04-16
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200180] R-HSA-2395849.6
summation	[Summation:2395825] NUDT1 (MTH1) catalyzes the reaction of 8-oxo-dGTP and water ...
(hasEvent)	[Pathway:2393930] Phosphate bond hydrolysis by NUDT proteins [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775878] Update Tracker - [Reaction:2395849] NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP - v78:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference] [_UpdateTracker:9786481] Update Tracker - [Reaction:2395849] NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP - v49:[addLiteratureReference, modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (2395849)