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Details on Person Phosphorylation of LAT by p-SYK

Class:Id	Reaction:2395801
_displayName	Phosphorylation of LAT by p-SYK
_doRelease	TRUE
_timestamp	2012-09-03 10:22:41
authored	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
catalystActivity	[CatalystActivity:2396614] protein tyrosine kinase activity of DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2395796] Garapati, P V, 2012-07-02
edited	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [EntityWithAccessionedSequence:2396548] LAT-2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:434839] Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes [LiteratureReference:2395792] Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells [LiteratureReference:2396554] Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity
modified	[InstanceEdit:2396616] Garapati, P V, 2012-07-09 [InstanceEdit:2424475] Garapati, P V, 2012-07-23 [InstanceEdit:2426120] Garapati, P V, 2012-07-27 [InstanceEdit:2428958] Garapati, P V, 2012-08-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of LAT by p-SYK
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:2396597] p-5Y-LAT-2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:2395412] Phosphorylation of SYK [Homo sapiens] [Reaction:210289] Recruitment of SYK to p-DAP12 [Homo sapiens]
releaseDate	2012-09-18
reviewed	[InstanceEdit:2428957] Lanier, Lewis L, 2012-08-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464910] R-HSA-2395801.2
summation	[Summation:2395799] LAT is palmitoylated and membrane-associated adaptor protein...
(hasEvent)	[Pathway:2424491] DAP12 signaling [Homo sapiens]
(precedingEvent)	[Reaction:2396599] Recruitment of GRB2:SOS to p-5Y-LAT [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787973] Update Tracker - [Reaction:2395801] Phosphorylation of LAT by p-SYK - v44:[modifyText]
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No pathways have been reviewed or authored by Phosphorylation of LAT by p-SYK (2395801)