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Details on Person FDXR transfers electrons to FDX1,2 (FDX1L)

Class:IdReaction:2395512
_displayNameFDXR transfers electrons to FDX1,2 (FDX1L)
_doReleaseTRUE
_timestamp2025-06-16 12:39:07
authored[InstanceEdit:2473458] Lill, R, 2012-09-24
[InstanceEdit:1362415] May, B, 2011-06-04
catalystActivity[CatalystActivity:9954152] ferredoxin-NADP+ reductase activity of FDXR [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:2395513] May, B, 2012-07-02
edited[InstanceEdit:2395514] May, B, 2012-06-29
input[Complex:2395502] FDXR:FADH2 [mitochondrial matrix] [Homo sapiens]
[DefinedSet:2408370] FDX1,FDX2 (oxidized) [mitochondrial matrix] [Homo sapiens]
[DefinedSet:2408370] FDX1,FDX2 (oxidized) [mitochondrial matrix] [Homo sapiens]
internalReviewed[InstanceEdit:9954136] D'Eustachio, Peter, 2025-06-06
isChimericFALSE
literatureReference[LiteratureReference:2395461] Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis
[LiteratureReference:2395466] Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis
modified[InstanceEdit:2395518] May, B, 2012-07-02
[InstanceEdit:2408373] May, B, 2012-07-16
[InstanceEdit:2426693] May, B, 2012-08-08
[InstanceEdit:2463806] May, B, 2012-08-30
[InstanceEdit:2473460] May, B, 2012-09-24
[InstanceEdit:2520970] May, B, 2012-10-11
[InstanceEdit:2559593] May, B, 2012-11-02
[InstanceEdit:5255114] May, B, 2014-02-06
[InstanceEdit:9676129] May, Bruce, 2020-02-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9954149] D'Eustachio, Peter, 2025-06-06
[InstanceEdit:9954172] D'Eustachio, Peter, 2025-06-06
[InstanceEdit:9956891] D'Eustachio, Peter, 2025-06-16
nameFDXR transfers electrons to FDX1,2 (FDX1L)
output[Complex:2395508] FDXR:FAD [mitochondrial matrix] [Homo sapiens]
[SimpleEntity:113529] H+ [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
[DefinedSet:2408372] FDX1,FDX2 (reduced) [mitochondrial matrix] [Homo sapiens]
[DefinedSet:2408372] FDX1,FDX2 (reduced) [mitochondrial matrix] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2012-12-04
reviewed[InstanceEdit:2520930] Rouault, Tracey A, 2012-10-11
[InstanceEdit:2520940] Tong, Wing-Hang, 2012-10-11
[InstanceEdit:9956890] Hill, David P, 2025-06-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3200207] R-HSA-2395512.4
structureModified[InstanceEdit:9954149] D'Eustachio, Peter, 2025-06-06
summation[Summation:2395451] Two electrons are transferred from reduced ferredoxin reduct...
(hasEvent)[Pathway:2395516] Electron transport from NADPH to Ferredoxin [Homo sapiens]
(precedingEvent)[BlackBoxEvent:1362408] FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster [Homo sapiens]
(updatedInstance)[_UpdateTracker:9964661] Update Tracker - [Reaction:2395512] FDXR transfers electrons to FDX1,2 (FDX1L) - v94:[removeCatalystActivity]
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