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Details on Person Latent TGF-beta-1 binds integrins

Class:IdReaction:2395320
_displayNameLatent TGF-beta-1 binds integrins
_doReleaseTRUE
_timestamp2021-08-17 14:06:23
authored[InstanceEdit:2214334] Jupe, S, 2012-04-30
compartment[Compartment:876] plasma membrane
created[InstanceEdit:2395344] Jupe, S, 2012-06-29
edited[InstanceEdit:2580335] Jupe, S, 2012-11-12
input[DefinedSet:2396176] LAP1 binding-integrins [plasma membrane] [Homo sapiens]
[Complex:9737594] LTBP1:TGFB1:LAP1 [extracellular region] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:2395368] Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1
[LiteratureReference:2395371] The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
[LiteratureReference:2395234] The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3
[LiteratureReference:2395246] The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1
[LiteratureReference:2395309] Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1
modified[InstanceEdit:2396250] Jupe, S, 2012-07-09
[InstanceEdit:2426629] Jupe, S, 2012-08-08
[InstanceEdit:2457637] Matthews, L, 2012-08-27
[InstanceEdit:2550419] Jupe, S, 2012-11-02
[InstanceEdit:2580335] Jupe, S, 2012-11-12
[InstanceEdit:2580336] Jupe, S, 2012-11-12
[InstanceEdit:9737597] Orlic-Milacic, Marija, 2021-07-20
[InstanceEdit:9751076] Orlic-Milacic, Marija, 2021-08-17
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameLatent TGF-beta-1 binds integrins
output[Complex:2396201] LTBP1:TGFB1:LAP1:LAP1-binding integrins [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2012-12-04
reviewed[InstanceEdit:2550420] Muiznieks, Lisa, 2012-11-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3200380] R-HSA-2395320.3
summation[Summation:2395334] The LAPs of TGF beta-1 and TGF beta-3 contain RGD sequences ...
(hasEvent)[Pathway:2129379] Molecules associated with elastic fibres [Homo sapiens]
[Pathway:2173789] TGF-beta receptor signaling activates SMADs [Homo sapiens]
[Pathway:9753549] TGF-beta ligand biogenesis, secretion and activation [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9748694] Thrombin-, ROCK1- and integrin-mediated release of active TGFB1 [Homo sapiens]
[BlackBoxEvent:9846184] GOCAM Thrombin-, ROCK1- and integrin-mediated release of active TGFB1 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775577] Update Tracker - [Reaction:2395320] Latent TGF-beta-1 binds integrins - v78:[add_removeInput]
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No pathways have been reviewed or authored by Latent TGF-beta-1 binds integrins (2395320)
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