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Details on Person Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP

Class:Id	Reaction:2393939
_displayName	Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP
_doRelease	TRUE
_timestamp	2025-12-16 18:01:26
authored	[InstanceEdit:2395962] D'Eustachio, P, 2012-07-06
catalystActivity	[CatalystActivity:2393952] ADP-ribose diphosphatase activity of NUDT5 dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643529] ADP-ribose diphosphatase activity of NUDT5 dimer [cytosol] Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2393942] D'Eustachio, P, 2012-06-27
crossReference	[DatabaseIdentifier:9976360] RHEA:10413
edited	[InstanceEdit:2395962] D'Eustachio, P, 2012-07-06
input	[SimpleEntity:1131972] ADP-D-ribose [cytosol] [SimpleEntity:29356] H2O [cytosol]
internalReviewed	[InstanceEdit:9977060] D'Eustachio, Peter, 2025-12-16
isChimeric	FALSE
literatureReference	[LiteratureReference:2393953] Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity [LiteratureReference:2393921] Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies [LiteratureReference:2393929] Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein
modified	[InstanceEdit:2395960] D'Eustachio, P, 2012-07-06 [InstanceEdit:2399542] D'Eustachio, P, 2012-07-10 [InstanceEdit:2509808] D'Eustachio, P, 2012-10-05 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9726061] D'Eustachio, Peter, 2021-04-02 [InstanceEdit:9731172] D'Eustachio, Peter, 2021-05-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10 [InstanceEdit:9977061] D'Eustachio, Peter, 2025-12-16 [InstanceEdit:9977063] D'Eustachio, Peter, 2025-12-16
name	Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP ADP-D-ribose + H2O => D-ribose 5-phosphate + AMP + 2 H(+)
output	[SimpleEntity:76577] AMP [cytosol] [SimpleEntity:73578] R5P [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-12-04
reviewed	[InstanceEdit:2509804] Ito, Riyoko, 2012-10-05 [InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200172] R-HSA-2393939.6
structureModified	[InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10
summation	[Summation:2393911] Cytosolic NUDT5 dimer (ADP-ribose pyrophosphatase) catalyzes...
(hasEvent)	[Pathway:2393930] Phosphate bond hydrolysis by NUDT proteins [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984656] Update Tracker - [Reaction:2393939] Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP - v96:[removeOutput]
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