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Details on Person UniProt:Q8NHV4 NEDD1
| Class:Id | ReferenceGeneProduct:239134 |
|---|---|
| _chainChangeLog | chain:1-660 added on Fri February 6 2015 |
| _displayName | UniProt:Q8NHV4 NEDD1 |
| _timestamp | 2026-02-20 23:08:14 |
| chain | chain:1-660 |
| checksum | 12817A567C13098B |
| comment | FUNCTION Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.SUBUNIT Interacts with FAM29A (PubMed:19029337). Interacts with HSPA1A and HSPA1B. Interacts with gamma-tubulin in a HSPA1A/B-dependent manner (PubMed:27137183).INTERACTION During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Protein NEDD1 alternativeName: Neural precursor cell expressed developmentally down-regulated protein 1 shortName: NEDD-1 |
| geneName | NEDD1 |
| identifier | Q8NHV4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Cell division Cytoplasm Cytoskeleton Mitosis Phosphoprotein Proteomics identification Reference proteome Repeat WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | NEDD1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991421] ENSEMBL:ENSG00000139350 NEDD1 [Homo sapiens] |
| secondaryIdentifier | NEDD1_HUMAN B0AZN0 B4E145 G3V3F1 Q8NA30 |
| sequenceLength | 660 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8964891] UniProt:Q8NHV4-1 NEDD1 [Homo sapiens] [ReferenceIsoform:8964892] UniProt:Q8NHV4-2 NEDD1 [Homo sapiens] [ReferenceIsoform:8964893] UniProt:Q8NHV4-3 NEDD1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:379267] NEDD1 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8NHV4 NEDD1 (239134)
