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Details on Person UniProt:Q9GZM8-2 NDEL1
| Class:Id | ReferenceIsoform:239033 |
|---|---|
| _chainChangeLog | chain:1-345 added on Sat February 7 2015 |
| _displayName | UniProt:Q9GZM8-2 NDEL1 |
| _timestamp | 2025-05-21 21:19:42 |
| chain | chain:1-345 |
| checksum | E91EA053FCA315D7 |
| comment | FUNCTION Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709).SUBUNIT Interacts with PLEKHM1 (via N- and C-terminus) (By similarity). Interacts with YWHAE. Interacts directly with NEFL and indirectly with NEFH. Interacts with microtubules (By similarity). Self-associates. Interacts with DISC1, dynein, dynactin, tubulin gamma, KATNA1, KATNB1, PAFAH1B1, PCM1 and PCNT. Interacts (via C-terminus) with CENPF. Interacts with ZNF365. Interacts with GTP-bound RAB9A; the interaction may lead to RAB9A-dynein motor tethering (PubMed:34793709).INTERACTION Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner.ALTERNATIVE PRODUCTS Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.DEVELOPMENTAL STAGE Expression peaks in mitosis.PTM Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE.PTM Palmitoylation at Cys-273 reduces affinity for dynein.SIMILARITY Belongs to the nudE family.CAUTION Was originally thought to function as an oligopeptidase (NUDEL-oligopeptidase or endooligopeptidase A) which could regulate peptide levels relevant to brain function. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Nuclear distribution protein nudE-like 1 shortName: Protein Nudel alternativeName: Mitosin-associated protein 1 |
| geneName | NDEL1 EOPA MITAP1 NUDEL |
| identifier | Q9GZM8 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Centromere Chromosome Coiled coil Cytoplasm Cytoskeleton Developmental protein Differentiation Kinetochore Lipoprotein Microtubule Neurogenesis Palmitate Phosphoprotein Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | NDEL1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000178] ENSEMBL:ENSG00000166579 NDEL1 [Homo sapiens] |
| secondaryIdentifier | NDEL1_HUMAN B3KP93 D3DTS0 J3QT32 Q86T80 Q8TAR7 Q9UH50 |
| sequenceLength | 345 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9GZM8-2 |
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No pathways have been reviewed or authored by UniProt:Q9GZM8-2 NDEL1 (239033)
