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Details on Person UniProt:Q969V3 NCLN
| Class:Id | ReferenceGeneProduct:238978 |
|---|---|
| _chainChangeLog | signal peptide:1-42 added on Fri February 6 2015;chain:43-563 added on Fri February 6 2015 |
| _displayName | UniProt:Q969V3 NCLN |
| _timestamp | 2024-11-03 20:20:18 |
| chain | signal peptide:1-42 chain:43-563 |
| checksum | 5E74EDF6ABA6F44F |
| comment | FUNCTION Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity).SUBUNIT Component of the back of Sec61 (BOS) complex, composed of NCLN/Nicalin, NOMO (NOMO1, NOMO2 or NOMO3) and TMEM147 (PubMed:15257293, PubMed:20538592, PubMed:36261522). The BOS complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47) (PubMed:32820719, PubMed:36261522). The MPT complex associates with the SEC61 complex (PubMed:32820719, PubMed:36261522).INTERACTION Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.SIMILARITY Belongs to the nicastrin family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="12"BOS complex subunit NCLN alternativeName: fullName evidence="9"Nicalin alternativeName: Nicastrin-like protein |
| geneName | NCLN |
| identifier | Q969V3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Endoplasmic reticulum Glycoprotein Membrane Proteomics identification Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NCLN |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003092] ENSEMBL:ENSG00000125912 NCLN [Homo sapiens] |
| secondaryIdentifier | NCLN_HUMAN D6W613 O75252 Q6FI60 Q6ZMB7 Q8TAT7 Q96H48 Q96IS7 Q9BQH9 Q9BTX4 Q9NPP2 |
| sequenceLength | 563 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:238979] UniProt:Q969V3-2 NCLN [Homo sapiens] [ReferenceIsoform:412608] UniProt:Q969V3-1 NCLN [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8932565] NCLN [endoplasmic reticulum membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q969V3 NCLN (238978)
