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Details on Person UniProt:Q8VDD5 Myh9
| Class:Id | ReferenceGeneProduct:238333 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-1960 added on Sat February 7 2015;initiator methionine:1 for 238333 removed on Fri Nov 03 2023;initiator methionine: for 238333 added on Fri Nov 03 2023;initiator methionine: for 238333 removed on Fri Aug 15 2025;initiator methionine:1 for 238333 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q8VDD5 Myh9 |
| _timestamp | 2025-08-15 22:09:51 |
| chain | initiator methionine:1 chain:2-1960 |
| checksum | AAAC0E83A0A4F24A |
| comment | FUNCTION Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (PubMed:19401332). Required for cortical actin clearance prior to oocyte exocytosis (PubMed:31118423). Promotes cell motility in conjunction with S100A4 (By similarity). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity).SUBUNIT Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with RASIP1 (PubMed:21396893). Interacts with DDR1 (PubMed:19401332). Interacts with PDLIM2 (By similarity). Interacts with SVIL (By similarity). Interacts with HTRA3 (By similarity). Interacts with Myo7a (PubMed:27331610). Interacts with CFAP95 (By similarity). Interacts with LIMCH1; independently of the integration of MYH9 into the myosin complex (By similarity). Interacts with RAB3A (By similarity). Interacts with ZBED4 (By similarity). Interacts with S100A4; this interaction increases cell motility.INTERACTION Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (By similarity). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (By similarity).DEVELOPMENTAL STAGE In neonatal mouse cochlea, weak levels of expression in both hair cells and supporting cells (at protein level). In the cochlea of six day old mice, expression is restricted to hair cell sterocilia (at protein level).DOMAIN The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.PTM ISGylated.PTM Ubiquitination.DISRUPTION PHENOTYPE Reduced litter size and increased polyspermy in the perivitelline space following fertilization.SIMILARITY Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Myosin-9 alternativeName: Cellular myosin heavy chain, type A alternativeName: Myosin heavy chain 9 alternativeName: Myosin heavy chain, non-muscle IIa alternativeName: Non-muscle myosin heavy chain A shortName: NMMHC-A alternativeName: Non-muscle myosin heavy chain IIa shortName: NMMHC II-a shortName: NMMHC-IIA |
| geneName | Myh9 |
| identifier | Q8VDD5 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Actin-binding ATP-binding Calmodulin-binding Cell adhesion Cell shape Coiled coil Cytoplasm Cytoplasmic vesicle Cytoskeleton Direct protein sequencing Methylation Motor protein Myosin Nucleotide-binding Phosphoprotein Reference proteome Ubl conjugation |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2455454] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Myh9 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MYH9_MOUSE Q3UHT9 Q3UHU4 Q6KAN6 Q811I2 |
| sequenceLength | 1960 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:1449615] Myh9 [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q8VDD5 Myh9 (238333)
