Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person UniProt:Q8N339 MT1M

Class:IdReferenceGeneProduct:238020
_chainChangeLogchain:1-61 added on Fri February 6 2015
_displayNameUniProt:Q8N339 MT1M
_timestamp2024-11-03 19:52:40
chainchain:1-61
checksum754753ED088411CE
commentFUNCTION Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.SUBUNIT Monomer.INTERACTION Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.SIMILARITY Belongs to the metallothionein superfamily. Type 1 family.
created[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
descriptionrecommendedName: Metallothionein-1M shortName: MT-1M alternativeName: Metallothionein-IM shortName: MT-IM
geneNameMT1M
MT1K
identifierQ8N339
isSequenceChangedFALSE
keywordCadmium
Copper
Metal-binding
Metal-thiolate cluster
Proteomics identification
Reference proteome
Zinc
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
nameMT1M
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:5660083] ENSEMBL:ENSG00000205364 MT1M [Homo sapiens]
secondaryIdentifierMT1M_HUMAN
Q8TDN3
sequenceLength61
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:5660422] MT1M [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:8957584] MT1M [extracellular region] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q8N339 MT1M (238020)