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Details on Person UniProt:Q8NHP6 MOSPD2
| Class:Id | ReferenceGeneProduct:237980 |
|---|---|
| _chainChangeLog | chain:1-518 added on Fri February 6 2015 |
| _displayName | UniProt:Q8NHP6 MOSPD2 |
| _timestamp | 2024-11-03 19:37:37 |
| chain | chain:1-518 |
| checksum | 6CC5920CF3B251E2 |
| comment | FUNCTION Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins (PubMed:29858488, PubMed:33124732, PubMed:35389430). In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis (PubMed:35389430). The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs (PubMed:35389430). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892).SUBUNIT Homooligomer (PubMed:33124732). Interacts (via MSP domain) with STARD3NL (via FFAT motif), RMDN3 (via FFAT motif), OSBPL1A (via FFAT motif) and CERT1 (via FFAT motif) (PubMed:29858488, PubMed:33124732). Interacts (via MSP domain) with STARD3 (via phosphorylated FFAT motif); this interaction depends on the critical phosphorylation of STARD3 on 'Ser-209' (PubMed:29858488, PubMed:33124732). Interacts with RB1CC1 (via phosphorylated FFAT motif), MIGA2 (via phosphorylated FFAT motif) and OSBPL1A (via FFAT motif) (PubMed:33124732).INTERACTION Localization to contact sites involving the endoplasmic reticulum and several organelles is regulated by interaction with proteins containing FFAT motif (PubMed:29858488). Dynamically distributes between specific subdomains of the endoplasmic reticulum (ER): ER membranes in contact with lipid droplets (LDs) and the remainder of the ER (PubMed:35389430).ALTERNATIVE PRODUCTS Highly expressed in CD14(+) monocytes, and at lower levels in neutrophils. Does not show significant expression in B-cells or T-cells.DOMAIN The MSP domain is required for binding to the FFAT motif of target proteins.DOMAIN The CRAL-TRIO domain is necessary for the recruitment to lipid droplets (LDs) and mediates the formation of ER-LDs contacts through an amphipathic helix.DOMAIN The transmembrane domain is necessary for binding to LDs. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="8"Motile sperm domain-containing protein 2 |
| geneName | MOSPD2 |
| identifier | Q8NHP6 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Chemotaxis Endoplasmic reticulum Membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MOSPD2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991981] ENSEMBL:ENSG00000130150 MOSPD2 [Homo sapiens] |
| secondaryIdentifier | MSPD2_HUMAN Q8N3H2 Q8NA83 |
| sequenceLength | 518 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:237981] UniProt:Q8NHP6-2 MOSPD2 [Homo sapiens] [ReferenceIsoform:411617] UniProt:Q8NHP6-1 MOSPD2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6799635] MOSPD2 [specific granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6806308] MOSPD2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9715095] MOSPD2 [endosome membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8NHP6 MOSPD2 (237980)
