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Details on Person UniProt:Q5VT66 MTARC1
| Class:Id | ReferenceGeneProduct:237714 |
|---|---|
| _chainChangeLog | chain:1-337 added on Fri February 6 2015;chain:1-337 removed on Fri February 12 2016;initiator methionine:1 added on Fri February 12 2016;chain:2-337 added on Fri February 12 2016;initiator methionine:1 for 237714 removed on Fri Nov 03 2023;initiator methionine: for 237714 added on Fri Nov 03 2023;initiator methionine: for 237714 removed on Fri Aug 15 2025;initiator methionine:1 for 237714 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q5VT66 MTARC1 |
| _timestamp | 2025-08-15 22:01:45 |
| chain | initiator methionine:1 chain:2-337 |
| checksum | F983AB08F3D646C4 |
| comment | FUNCTION Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:19053771, PubMed:21029045, PubMed:30397129). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:19053771). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:19053771, PubMed:21029045).CATALYTIC ACTIVITY N(omega)-hydroxy-L-arginine + 2 Fe(II)-[cytochrome b5] + 2 H(+) = L-arginine + 2 Fe(III)-[cytochrome b5] + H2OCOFACTOR Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.BIOPHYSICOCHEMICAL PROPERTIES Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase and MTARC1.INTERACTION Mitochondrial import is mediated by AA 1-40 and requires ATP.ALTERNATIVE PRODUCTS Comprises two structural domains, the molybdenum cofactor/Moco sulfurase C-terminal (MOSC) domain and the MOSC N-terminal region, forming a cleft that accommodates Moco. The MOSC domain, which contains a large seven-stranded mostly antiparallel beta-barrel, engages multiple interactions with Moco both pterin ring and phosphate group, allowing for a tight coordination of Moco within the core of the enzyme. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="15"Mitochondrial amidoxime-reducing component 1 shortName evidence="16"mARC1 ecNumber evidence="6"1.7.-.- alternativeName: fullName evidence="16"Molybdenum cofactor sulfurase C-terminal domain-containing protein 1 shortName: MOSC domain-containing protein 1 shortName: Moco sulfurase C-terminal domain-containing protein 1 |
| geneName | MTARC1 MARC1 MOSC1 |
| identifier | Q5VT66 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Lipoprotein Membrane Metal-binding Mitochondrion Mitochondrion outer membrane Molybdenum Myristate Oxidoreductase Proteomics identification Reference proteome Signal-anchor Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | MTARC1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000684] ENSEMBL:ENSG00000186205 MTARC1 [Homo sapiens] |
| secondaryIdentifier | MARC1_HUMAN A8K447 B2D078 Q5VVS9 Q5VVT0 Q5VVT1 Q8N9P5 Q96FN8 Q9H6C7 |
| sequenceLength | 337 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:237715] UniProt:Q5VT66-2 MTARC1 [Homo sapiens] [ReferenceIsoform:237716] UniProt:Q5VT66-3 MTARC1 [Homo sapiens] [ReferenceIsoform:407466] UniProt:Q5VT66-1 MTARC1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8936417] MARC1 [mitochondrial outer membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q5VT66 MTARC1 (237714)
