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Details on Person UniProt:Q9BUB5-3 MKNK1
| Class:Id | ReferenceIsoform:237467 |
|---|---|
| _chainChangeLog | chain:1-465 added on Fri February 6 2015 |
| _displayName | UniProt:Q9BUB5-3 MKNK1 |
| _timestamp | 2025-02-21 18:58:51 |
| chain | chain:1-465 |
| checksum | CAE225C35DCB2B43 |
| comment | FUNCTION May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)COFACTOR Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway.SUBUNIT Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2, and to the p38 kinases.INTERACTION Ubiquitous.PTM Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1.SIMILARITY Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: MAP kinase-interacting serine/threonine-protein kinase 1 ecNumber evidence="4 8"2.7.11.1 alternativeName: MAP kinase signal-integrating kinase 1 shortName: MAPK signal-integrating kinase 1 shortName: Mnk1 |
| geneName | MKNK1 MNK1 |
| identifier | Q9BUB5 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Cytoplasm Kinase Magnesium Metal-binding Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase Transferase Translation regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MKNK1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000696] ENSEMBL:ENSG00000079277 MKNK1 [Homo sapiens] |
| secondaryIdentifier | MKNK1_HUMAN D3DQ20 D3DQ21 O00312 Q5TC06 Q5TC07 Q6V0N6 |
| sequenceLength | 465 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9BUB5-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9BUB5-3 MKNK1 (237467)
