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Details on Person UniProt:Q9H2W2 MIXL1
| Class:Id | ReferenceGeneProduct:237447 |
|---|---|
| _chainChangeLog | chain:1-232 added on Fri February 6 2015 |
| _displayName | UniProt:Q9H2W2 MIXL1 |
| _timestamp | 2024-11-03 19:57:15 |
| chain | chain:1-232 |
| checksum | 2E8A6A811799A8F0 |
| comment | FUNCTION Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity).SUBCELLULAR LOCATION Restricted to progenitors and secondary lymph tissues. In normal hematopoiesis, it is restricted to immature B- and T-lymphoid cells. Present in differentiating embryonic stem cells (at protein level).PTM Phosphorylated at multiple sites.SIMILARITY Belongs to the paired homeobox family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Homeobox protein MIXL1 alternativeName: Homeodomain protein MIX shortName: hMix alternativeName: MIX1 homeobox-like protein 1 alternativeName: Mix.1 homeobox-like protein |
| geneName | MIXL1 MIXL |
| identifier | Q9H2W2 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Developmental protein Differentiation DNA-binding Homeobox Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MIXL1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988504] ENSEMBL:ENSG00000185155 MIXL1 [Homo sapiens] |
| secondaryIdentifier | MIXL1_HUMAN B7ZLF9 |
| sequenceLength | 232 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8969754] UniProt:Q9H2W2-1 MIXL1 [Homo sapiens] [ReferenceIsoform:8969755] UniProt:Q9H2W2-2 MIXL1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9758510] MIXL1 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9H2W2 MIXL1 (237447)
