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Details on Person UniProt:Q920G8 Slc25a37
| Class:Id | ReferenceGeneProduct:237239 |
|---|---|
| _chainChangeLog | chain:1-338 added on Fri February 6 2015 |
| _displayName | UniProt:Q920G8 Slc25a37 |
| _timestamp | 2023-11-03 16:05:07 |
| chain | chain:1-338 |
| checksum | BB35B1F70C56A3FE |
| comment | FUNCTION Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis.CATALYTIC ACTIVITY Fe(2+)(in) = Fe(2+)(out)SUBUNIT Interacts with ACB10; this interaction stabilizes SLC25A37 and enhances the function of SLC25A37 to import mitochondrial iron during erythroid differentiation.SUBCELLULAR LOCATION Highly expressed in hematopoietic organs, fetal liver, bone marrow and spleen.DEVELOPMENTAL STAGE In the developing embryo, it is first detected at 7.5 dpc in the extraembryonic yolk sac, coincident with the appearance of blood islands. Later, restricted expression is seen in 14.5 dpc fetal liver, the primary source of erythrocyte production in mid-gestation. Expression decreases in the spleen around 4-5 weeks of age, suggesting that it is decreased during splenic lymphocyte maturation.DISRUPTION PHENOTYPE Erythroblasts generated from murine embryonic stem cells null for Slc25a37/Mfrn show maturation arrest with severely impaired incorporation of iron into heme.SIMILARITY Belongs to the mitochondrial carrier (TC 2.A.29) family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Mitoferrin-1 alternativeName: Mitochondrial iron transporter 1 alternativeName: Mitochondrial solute carrier protein alternativeName: Solute carrier family 25 member 37 |
| geneName | Slc25a37 Mfrn Mscp |
| identifier | Q920G8 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Direct protein sequencing Ion transport Iron Iron transport Membrane Mitochondrion Mitochondrion inner membrane Reference proteome Repeat Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Slc25a37 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MFRN1_MOUSE Q8C367 Q8CEJ7 Q91ZY0 Q9D2G3 Q9D547 |
| sequenceLength | 338 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:237240] UniProt:Q920G8-2 Slc25a37 [Mus musculus] [ReferenceIsoform:237241] UniProt:Q920G8-3 Slc25a37 [Mus musculus] [ReferenceIsoform:237242] UniProt:Q920G8-4 Slc25a37 [Mus musculus] [ReferenceIsoform:237243] UniProt:Q920G8-5 Slc25a37 [Mus musculus] [ReferenceIsoform:412365] UniProt:Q920G8-1 Slc25a37 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:1362397] Slc25a37 [mitochondrial inner membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q920G8 Slc25a37 (237239)
