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Details on Person UniProt:Q9NWA0 MED9
| Class:Id | ReferenceGeneProduct:237105 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-146 added on Fri February 6 2015;initiator methionine:1 for 237105 removed on Fri Nov 03 2023;initiator methionine: for 237105 added on Fri Nov 03 2023;initiator methionine: for 237105 removed on Fri Aug 15 2025;initiator methionine:1 for 237105 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9NWA0 MED9 |
| _timestamp | 2025-08-15 21:46:40 |
| chain | initiator methionine:1 chain:2-146 |
| checksum | 24CDB7CBDFD36D1A |
| comment | FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.INTERACTION Belongs to the Mediator complex subunit 9 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Mediator of RNA polymerase II transcription subunit 9 alternativeName: Mediator complex subunit 9 |
| geneName | MED9 MED25 |
| identifier | Q9NWA0 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Activator Coiled coil Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | MED9 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962134] ENSEMBL:ENSG00000141026 MED9 [Homo sapiens] |
| secondaryIdentifier | MED9_HUMAN |
| sequenceLength | 146 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:556804] MED9 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NWA0 MED9 (237105)
