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Details on Person UniProt:A0JLT2-2 MED19
| Class:Id | ReferenceIsoform:237014 |
|---|---|
| _chainChangeLog | chain:1-244 added on Fri February 6 2015 |
| _displayName | UniProt:A0JLT2-2 MED19 |
| _timestamp | 2024-11-03 20:10:45 |
| chain | chain:1-244 |
| checksum | 9B85721364F33F02 |
| comment | FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.INTERACTION Belongs to the Mediator complex subunit 19 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Mediator of RNA polymerase II transcription subunit 19 alternativeName: Lung cancer metastasis-related protein 1 alternativeName: Mediator complex subunit 19 |
| geneName | MED19 LCMR1 |
| identifier | A0JLT2 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MED19 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000152] ENSEMBL:ENSG00000156603 MED19 [Homo sapiens] |
| secondaryIdentifier | MED19_HUMAN Q8IV02 Q8IZD1 |
| sequenceLength | 244 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | A0JLT2-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:A0JLT2-2 MED19 (237014)
