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Details on Person UniProt:Q6PGF3 Med16
| Class:Id | ReferenceGeneProduct:236998 |
|---|---|
| _chainChangeLog | chain:1-828 added on Sat February 7 2015 |
| _displayName | UniProt:Q6PGF3 Med16 |
| _timestamp | 2023-11-03 15:18:28 |
| chain | chain:1-828 |
| checksum | 6388AEF86575997D |
| comment | FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).SUBCELLULAR LOCATION Belongs to the Mediator complex subunit 16 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Mediator of RNA polymerase II transcription subunit 16 alternativeName: Mediator complex subunit 16 alternativeName: Thyroid hormone receptor-associated protein 5 alternativeName: Thyroid hormone receptor-associated protein complex 95 kDa component shortName: Trap95 alternativeName: Vitamin D3 receptor-interacting protein complex 92 kDa component shortName: DRIP92 |
| geneName | Med16 Thrap5 |
| identifier | Q6PGF3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Nucleus Reference proteome Repeat Transcription Transcription regulation WD repeat |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9765872] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Med16 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MED16_MOUSE E9QM81 |
| sequenceLength | 828 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:556792] Med16 [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q6PGF3 Med16 (236998)
