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Details on Person UniProt:Q9BTT4 MED10
| Class:Id | ReferenceGeneProduct:236972 |
|---|---|
| _chainChangeLog | chain:1-135 added on Fri February 6 2015 |
| _displayName | UniProt:Q9BTT4 MED10 |
| _timestamp | 2024-11-03 19:41:51 |
| chain | chain:1-135 |
| checksum | F804CD76770149E1 |
| comment | FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.INTERACTION Belongs to the Mediator complex subunit 10 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Mediator of RNA polymerase II transcription subunit 10 alternativeName: Mediator complex subunit 10 alternativeName: Transformation-related gene 17 protein shortName: TRG-17 alternativeName: Transformation-related gene 20 protein shortName: TRG-20 |
| geneName | MED10 L6 TRG17 TRG20 |
| identifier | Q9BTT4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Nucleus Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MED10 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000151] ENSEMBL:ENSG00000133398 MED10 [Homo sapiens] |
| secondaryIdentifier | MED10_HUMAN C6G491 |
| sequenceLength | 135 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:212410] MED10 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9BTT4 MED10 (236972)
