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Details on Person UniProt:Q6JPI3 Med13l
| Class:Id | ReferenceGeneProduct:236915 |
|---|---|
| _chainChangeLog | chain:1-2207 added on Fri February 6 2015 |
| _displayName | UniProt:Q6JPI3 Med13l |
| _timestamp | 2023-11-03 15:09:25 |
| chain | chain:1-2207 |
| checksum | CC4CE8B90CF30338 |
| comment | FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway (By similarity).SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).SUBCELLULAR LOCATION Highly expressed in heart and weakly expressed in brain, spleen, lung, liver, kidney and testis.SIMILARITY Belongs to the Mediator complex subunit 13 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Mediator of RNA polymerase II transcription subunit 13-like alternativeName: Mediator complex subunit 13-like alternativeName: Thyroid hormone receptor-associated protein 2 alternativeName: Thyroid hormone receptor-associated protein complex 240 kDa component-like |
| geneName | Med13l Kiaa1025 Thrap2 Trap240l |
| identifier | Q6JPI3 |
| isSequenceChanged | FALSE |
| keyword | Activator Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Med13l |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MD13L_MOUSE Q3TRF4 Q3UQI8 Q80TM3 Q80WQ0 |
| sequenceLength | 2207 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:556806] Mediator of RNA polymerase II transcription subunit 13-like [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q6JPI3 Med13l (236915)
