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Details on Person UniProt:Q5SRI9 MANEA
| Class:Id | ReferenceGeneProduct:236596 |
|---|---|
| _chainChangeLog | chain:1-462 added on Fri February 6 2015 |
| _displayName | UniProt:Q5SRI9 MANEA |
| _timestamp | 2025-02-21 19:29:32 |
| chain | chain:1-462 |
| checksum | CB593CB9B3DAA056 |
| comment | CATALYTIC ACTIVITY N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] + H2O = alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 6.2.SUBCELLULAR LOCATION Highly expressed in the liver and kidney. Expressed at lower levels in muscle, pancreas, heart, placenta, lung and brain.PTM Undergoes proteolytic cleavage in the C-terminal region.SIMILARITY Belongs to the glycosyl hydrolase 99 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Glycoprotein endo-alpha-1,2-mannosidase shortName: Endo-alpha mannosidase shortName: Endomannosidase shortName: hEndo ecNumber evidence="2 3"3.2.1.130 alternativeName: Mandaselin |
| geneName | MANEA |
| identifier | Q5SRI9 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Golgi apparatus Hydrolase Membrane Proteomics identification Reference proteome Signal-anchor Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MANEA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992566] ENSEMBL:ENSG00000172469 MANEA [Homo sapiens] |
| secondaryIdentifier | MANEA_HUMAN A6H8M6 Q5SRJ0 Q6MZV0 Q70JE9 Q7Z3V7 Q8WWX5 Q9H9D2 |
| sequenceLength | 462 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:548903] MANEA [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:964729] MANEA [Golgi membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q5SRI9 MANEA (236596)
