Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person PIK3CA E545V [cytosol]

Class:IdEntityWithAccessionedSequence:2362365
_displayNamePIK3CA E545V [cytosol]
_timestamp2013-06-06 16:42:23
compartment[Compartment:70101] cytosol
created[InstanceEdit:2362364] Orlic-Milacic, M, 2012-06-27
crossReference[DatabaseIdentifier:2362363] COSMIC:COSM144201
disease[Disease:1500689] cancer
[Disease:1500575] ovarian cancer
endCoordinate1068
hasModifiedResidue[ReplacedResidue:2362367] L-glutamic acid 545 replaced with L-valine
literatureReference[LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
[LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
[LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
modified[InstanceEdit:2399603] Orlic-Milacic, M, 2012-07-11
[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
namePIK3CA E545V
PIK3CA Glu545Val
referenceEntity[ReferenceGeneProduct:61074] UniProt:P42336 PIK3CA [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2465221] R-HSA-2362365.1
startCoordinate1
summation[Summation:2399602] Based on structural and functional studies of the PIK3CA E54...
(hasCandidate)[CandidateSet:2399587] PIK3CA helical domain mutants [cytosol] [Homo sapiens]
(updatedInstance)[_UpdateTracker:9888250] Update Tracker - [EntityWithAccessionedSequence:2362365] PIK3CA E545V [cytosol] - v46:[modifyName]
[Change default viewing format]
No pathways have been reviewed or authored by PIK3CA E545V [cytosol] (2362365)
Follow Reactome