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Details on Person UniProt:Q93052 LPP
| Class:Id | ReferenceGeneProduct:235536 |
|---|---|
| _chainChangeLog | chain:1-612 added on Fri February 6 2015 |
| _displayName | UniProt:Q93052 LPP |
| _timestamp | 2024-11-03 19:37:21 |
| chain | chain:1-612 |
| checksum | 439CE0101FDE4DDD |
| comment | FUNCTION May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.SUBUNIT Interacts with VASP, with PDZ domains of SCRIB and with ACTN1/alpha-actinin.SUBCELLULAR LOCATION Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and KMT2A/MLL1.TISSUE SPECIFICITY Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes.DISEASE A chromosomal aberration involving LPP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with HMGA2 is shown in lipomas.DISEASE A chromosomal aberration involving LPP is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with HMGA2 is detected in pulmonary chondroid hamartomas.DISEASE A chromosomal aberration involving LPP is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with HMGA2 is also shown in one parosteal lipoma.DISEASE A chromosomal aberration involving LPP is associated with acute monoblastic leukemia. Translocation t(3;11)(q28;q23) with KMT2A/MLL1 is associated with acute monoblastic leukemia.SIMILARITY Belongs to the zyxin/ajuba family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Lipoma-preferred partner alternativeName: LIM domain-containing preferred translocation partner in lipoma |
| geneName | LPP |
| identifier | Q93052 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Activator Cell adhesion Cell junction Cell membrane Chromosomal rearrangement Cytoplasm Isopeptide bond LIM domain Membrane Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ubl conjugation Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | LPP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993723] ENSEMBL:ENSG00000145012 LPP [Homo sapiens] |
| secondaryIdentifier | LPP_HUMAN A1L4L6 D3DNV6 Q8NFX5 |
| sequenceLength | 612 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:432912] LPP [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q93052 LPP (235536)
