Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:Q86U10 ASPG

Class:Id	ReferenceGeneProduct:235506
_chainChangeLog	chain:1-573 added on Sat February 7 2015
_displayName	UniProt:Q86U10 ASPG
_timestamp	2025-02-21 20:00:45
chain	chain:1-573
checksum	62DBC583FF9C3AD7
comment	FUNCTION Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer) (By similarity). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid (By similarity).CATALYTIC ACTIVITY a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)CATALYTIC ACTIVITY L-asparagine + H2O = L-aspartate + NH4(+)CATALYTIC ACTIVITY a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)CATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)CATALYTIC ACTIVITY 2 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholineCATALYTIC ACTIVITY 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + sn-glycerol 3-phosphocholine + H(+)CATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = sn-glycero-3-phosphoethanolamine + hexadecanoate + H(+)CATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholineCATALYTIC ACTIVITY 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)CATALYTIC ACTIVITY 2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)CATALYTIC ACTIVITY 2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholineCATALYTIC ACTIVITY 1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O = 2-acetyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine = a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholineCATALYTIC ACTIVITY 2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholineSUBUNIT Monomer.INTERACTION May be due to a competing acceptor splice site.SIMILARITY In the N-terminal section; belongs to the asparaginase 1 family.SEQUENCE CAUTION Wrong choice of frame.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: 60 kDa lysophospholipase shortName: LysoLP ecNumber evidence="2"3.1.1.5 alternativeName: fullName evidence="2"Lysophospholipase-transacylase domain recommendedName: L-asparaginase ecNumber evidence="2"3.5.1.1 alternativeName: L-asparagine amidohydrolase /domain domain recommendedName: 1-alkyl-2-acetylglycerophosphocholine esterase ecNumber evidence="2"3.1.1.47 alternativeName: Platelet-activating factor acetylhydrolase shortName: PAF acetylhydrolase /domain
geneName	ASPG C14orf76
identifier	Q86U10
isSequenceChanged	FALSE
keyword	Acyltransferase Alternative splicing ANK repeat Hydrolase Lipid degradation Lipid metabolism Proteomics identification Reference proteome Repeat Transferase
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	ASPG
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8993722] ENSEMBL:ENSG00000166183 ASPG [Homo sapiens]
secondaryIdentifier	LPP60_HUMAN B9EGQ2 Q8IV80
sequenceLength	573
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:409808] UniProt:Q86U10-1 ASPG [Homo sapiens] [ReferenceIsoform:8976583] UniProt:Q86U10-3 ASPG [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:6797634] ASPG [cytosol] [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:Q86U10 ASPG (235506)