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Details on Person UniProt:O14910 LIN7A
| Class:Id | ReferenceGeneProduct:235143 |
|---|---|
| _chainChangeLog | chain:1-233 added on Fri February 6 2015 |
| _displayName | UniProt:O14910 LIN7A |
| _timestamp | 2024-11-03 19:51:59 |
| chain | chain:1-233 |
| checksum | D8D05EF16A93BE7B |
| comment | FUNCTION Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.SUBUNIT Forms a complex with CASK and CASKIN1 (By similarity). Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2-LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules (By similarity). Can also interact with other modular proteins containing protein-protein interaction domains like PALS1, PALS2, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4, GRIN2B and MARCHF11 as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4 (By similarity). Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C).INTERACTION Mainly basolateral in renal epithelial cells.TISSUE SPECIFICITY Expressed in brain, testis, kidney, placenta and liver.DOMAIN The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.DOMAIN The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.DOMAIN The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.SIMILARITY Belongs to the lin-7 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Protein lin-7 homolog A shortName: Lin-7A shortName: hLin-7 alternativeName: Mammalian lin-seven protein 1 shortName: MALS-1 alternativeName: Tax interaction protein 33 shortName: TIP-33 alternativeName: Vertebrate lin-7 homolog 1 shortName: Veli-1 |
| geneName | LIN7A MALS1 VELI1 |
| identifier | O14910 |
| isSequenceChanged | FALSE |
| keyword | Cell junction Cell membrane Exocytosis Membrane Postsynaptic cell membrane Protein transport Proteomics identification Reference proteome Synapse Tight junction Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | LIN7A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004780] ENSEMBL:ENSG00000111052 LIN7A [Homo sapiens] |
| secondaryIdentifier | LIN7A_HUMAN A4FTY3 Q147W1 Q6LES3 Q7LDS4 |
| sequenceLength | 233 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5216076] LIN7A [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9610413] LIN7A [transport vesicle membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O14910 LIN7A (235143)
