Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person UniProt:Q52LA3 LIN52

Class:IdReferenceGeneProduct:235140
_chainChangeLogchain:1-116 added on Sat February 7 2015;chain:1-116 for 235140 removed on Fri Feb 20 2026;chain:1-112 for 235140 added on Fri Feb 20 2026
_displayNameUniProt:Q52LA3 LIN52
_timestamp2026-05-15 20:53:21
chainchain:1-112
checksum58158451FDCFD363
commentSUBUNIT Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.INTERACTION Belongs to the lin-52 family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.
created[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
descriptionrecommendedName: Protein lin-52 homolog
geneNameLIN52
C14orf46
identifierQ52LA3
isSequenceChangedFALSE
keyword3D-structure
Phosphoprotein
Proteomics identification
Reference proteome
modified[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:5634237] Weiser, JD
[InstanceEdit:5673015] Weiser, JD
[InstanceEdit:6807888] Weiser, JD
[InstanceEdit:8987656] Weiser, JD
[InstanceEdit:9037114] Weiser, JD
[InstanceEdit:9637257] Weiser, JD
[InstanceEdit:9676415] Weiser, JD
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
[InstanceEdit:9989145] Weiser, Joel, 2026-05-15
nameLIN52
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:9003034] ENSEMBL:ENSG00000205659 LIN52 [Homo sapiens]
secondaryIdentifierLIN52_HUMAN
B3KN83
sequenceLength112
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:389107] LIN52 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:1362251] p-S28-LIN52 [nucleoplasm] [Homo sapiens]
(referenceSequence)[ModifiedResidue:1362250] O-phospho-L-serine at 28
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No pathways have been reviewed or authored by UniProt:Q52LA3 LIN52 (235140)