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Details on Person UniProt:Q6GTX8 LAIR1

Class:Id	ReferenceGeneProduct:234771
_chainChangeLog	signal peptide:1-21 added on Fri February 6 2015;chain:22-287 added on Fri February 6 2015
_displayName	UniProt:Q6GTX8 LAIR1
_timestamp	2025-05-21 21:30:55
chain	signal peptide:1-21 chain:22-287
checksum	E2A921D84F426B35
comment	FUNCTION Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.SUBUNIT Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK. Binds with high affinity to extracellular matrix collagens, the interaction is functionally important.INTERACTION Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection.DEVELOPMENTAL STAGE Complete loss of expression when naive B-cells proliferates and differentiates into Ig-producing plasma cells under in vitro stimulation.INDUCTION By T-cell receptor stimulation in a process that requires p38 MAP kinase and ERK signaling.DOMAIN ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present in 2 copies in the intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, leading to down-regulation of cell activation.PTM Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK.PTM N-glycosylated.MISCELLANEOUS Functions as an inhibitory receptor in NK cells and T-cells.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: Leukocyte-associated immunoglobulin-like receptor 1 shortName: LAIR-1 shortName: hLAIR1 cdAntigenNameCD305/cdAntigenName
geneName	LAIR1 CD305
identifier	Q6GTX8
isSequenceChanged	FALSE
keyword	3D-structure Adaptive immunity Alternative splicing Cell membrane Disulfide bond Glycoprotein Immunity Immunoglobulin domain Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
name	LAIR1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8995510] ENSEMBL:ENSG00000167613 LAIR1 [Homo sapiens]
secondaryIdentifier	LAIR1_HUMAN
sequenceLength	287
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:234772] UniProt:Q6GTX8-2 LAIR1 [Homo sapiens] [ReferenceIsoform:234773] UniProt:Q6GTX8-3 LAIR1 [Homo sapiens] [ReferenceIsoform:234774] UniProt:Q6GTX8-4 LAIR1 [Homo sapiens] [ReferenceIsoform:408218] UniProt:Q6GTX8-1 LAIR1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:5686426] LAIR1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6799644] LAIR1 [specific granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6800947] LAIR1 [tertiary granule membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q6GTX8 LAIR1 (234771)