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Details on Person UniProt:Q8VBY2 Camkk1
| Class:Id | ReferenceGeneProduct:234424 |
|---|---|
| _chainChangeLog | chain:1-505 added on Fri February 6 2015 |
| _displayName | UniProt:Q8VBY2 Camkk1 |
| _timestamp | 2025-02-21 18:58:01 |
| chain | chain:1-505 |
| checksum | 179915A25628F9C4 |
| comment | FUNCTION Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)ACTIVITY REGULATION Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Partially inhibited upon phosphorylation by PRCAKA/PKA (By similarity). May be regulated through phosphorylation by CAMK1 and CAMK4.SUBUNIT Interacts with CAMK4 and calmodulin.SUBCELLULAR LOCATION Widely expressed. Differentially expressed in various brain regions.DOMAIN The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.DOMAIN The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.PTM Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity).SIMILARITY Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Calcium/calmodulin-dependent protein kinase kinase 1 shortName: CaM-KK 1 shortName: CaM-kinase kinase 1 shortName: CaMKK 1 ecNumber: 2.7.11.17 alternativeName: CaM-kinase IV kinase alternativeName: Calcium/calmodulin-dependent protein kinase kinase alpha shortName: CaM-KK alpha shortName: CaM-kinase kinase alpha shortName: CaMKK alpha |
| geneName | Camkk1 Camkk |
| identifier | Q8VBY2 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Calmodulin-binding Cytoplasm Direct protein sequencing Kinase Methylation Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Camkk1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | KKCC1_MOUSE Q9R054 |
| sequenceLength | 505 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9618913] Camkk1 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9619242] Camkk1 [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q8VBY2 Camkk1 (234424)
