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Details on Person UniProt:Q9C0C6 CIPC
| Class:Id | ReferenceGeneProduct:233772 |
|---|---|
| _chainChangeLog | chain:1-399 added on Fri February 6 2015 |
| _displayName | UniProt:Q9C0C6 CIPC |
| _timestamp | 2024-11-03 20:09:21 |
| chain | chain:1-399 |
| checksum | A02AE8F6543781D9 |
| comment | FUNCTION Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK. However, the physiological relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock.SUBUNIT Interacts with CLOCK. Forms a ternary complex with the CLOCK-BMAL1 heterodimer. Interacts with CAD and HSPA5 (PubMed:26657846).INTERACTION Predominantly localizes to the nucleus, where it co-localizes with CLOCK. At the G1/S boundary, partially translocated to the cytosol.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: CLOCK-interacting pacemaker alternativeName: CLOCK-interacting circadian protein |
| geneName | CIPC KIAA1737 |
| identifier | Q9C0C6 |
| isSequenceChanged | FALSE |
| keyword | Biological rhythms Coiled coil Cytoplasm Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CIPC |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990028] ENSEMBL:ENSG00000198894 CIPC [Homo sapiens] |
| secondaryIdentifier | CIPC_HUMAN B2RCI1 Q8N389 Q8NDZ1 |
| sequenceLength | 399 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9911267] CIPC [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9C0C6 CIPC (233772)
