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Details on Person UniProt:O15054-2 KDM6B
| Class:Id | ReferenceIsoform:233298 |
|---|---|
| _chainChangeLog | chain:1-1643 added on Sat February 7 2015 |
| _displayName | UniProt:O15054-2 KDM6B |
| _timestamp | 2025-02-21 18:57:56 |
| chain | chain:1-1643 |
| checksum | 8CE32AE602683BA3 |
| comment | FUNCTION Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity).CATALYTIC ACTIVITY N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(27)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2COFACTOR Interacts with TLE1 (By similarity). Component of the MLL4 complex, at least composed of KMT2B/MLL4, ASH2L, RBBP5, WDR5, and KDM6B (PubMed:17825402). Interacts with TBX21, SMARCA4, SMARCC1 and SMARCC2 (By similarity).INTERACTION By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the UTX family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Lysine-specific demethylase 6B ecNumber evidence="7 8 9 10"1.14.11.68 alternativeName: JmjC domain-containing protein 3 alternativeName: Jumonji domain-containing protein 3 alternativeName: Lysine demethylase 6B alternativeName: fullName evidence="14"[histone H3]-trimethyl-L-lysine(27) demethylase 6B |
| geneName | KDM6B JMJD3 KIAA0346 |
| identifier | O15054 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Chromatin regulator Dioxygenase Disease variant Inflammatory response Intellectual disability Iron Isopeptide bond Metal-binding Nucleus Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Ubl conjugation Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | KDM6B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:3222525] ENSEMBL:ENSG00000132510 KDM6B [Homo sapiens] |
| secondaryIdentifier | KDM6B_HUMAN C9IZ40 Q96G33 |
| sequenceLength | 1643 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O15054-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O15054-2 KDM6B (233298)
