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Details on Person UniProt:Q6ZMT4 KDM7A
| Class:Id | ReferenceGeneProduct:233232 |
|---|---|
| _chainChangeLog | chain:1-941 added on Fri February 6 2015 |
| _displayName | UniProt:Q6ZMT4 KDM7A |
| _timestamp | 2025-02-21 18:57:56 |
| chain | chain:1-941 |
| checksum | AB8161020D157F11 |
| comment | FUNCTION Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (PubMed:20023638, PubMed:20622853). Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3 (PubMed:20023638). Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (PubMed:20622853).CATALYTIC ACTIVITY N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2CATALYTIC ACTIVITY N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(27)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2CATALYTIC ACTIVITY N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2-oxoglutarate + O2 = N(6)-methyl-L-lysyl(36)-[histone H3] + formaldehyde + succinate + CO2CATALYTIC ACTIVITY N(6)-methyl-L-lysyl(20)-[histone H4] + 2-oxoglutarate + O2 = L-lysyl(20)-[histone H4] + formaldehyde + succinate + CO2COFACTOR Binds 1 Fe(2+) ion per subunit.BIOPHYSICOCHEMICAL PROPERTIES The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 prevents its access to H3K9me2.DOMAIN The linker region is a critical determinant of demethylase specificity. It prevents the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3, while it favors selectivity toward H3K27me2.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Lysine-specific demethylase 7A alternativeName: JmjC domain-containing histone demethylation protein 1D alternativeName: Lysine-specific demethylase 7 alternativeName: [histone H3]-dimethyl-L-lysine9 demethylase 7A ecNumber evidence="6 7"1.14.11.65 |
| geneName | KDM7A JHDM1D KDM7 KIAA1718 |
| identifier | Q6ZMT4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Chromatin regulator Dioxygenase Iron Metal-binding Neurogenesis Nucleus Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | KDM7A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000118] ENSEMBL:ENSG00000006459 KDM7A [Homo sapiens] |
| secondaryIdentifier | KDM7A_HUMAN A4D1S9 C9JJH9 C9JQU2 Q6MZL8 Q9C0E5 |
| sequenceLength | 941 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:233233] UniProt:Q6ZMT4-2 KDM7A [Homo sapiens] [ReferenceIsoform:408872] UniProt:Q6ZMT4-1 KDM7A [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5423088] KDM7A [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6802391] KDM7A(1-476)-BRAF(439-766) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6802531] KDM7A(1-476)-p-BRAF(439-766) fusion [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q6ZMT4 KDM7A (233232)
