Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q6IE81 JADE1
| Class:Id | ReferenceGeneProduct:233204 |
|---|---|
| _chainChangeLog | chain:1-842 added on Fri February 6 2015 |
| _displayName | UniProt:Q6IE81 JADE1 |
| _timestamp | 2024-11-03 20:19:37 |
| chain | chain:1-842 |
| checksum | 239FC2229CE25FFD |
| comment | FUNCTION Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112).SUBUNIT Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3 (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:29382722). Interacts with NPHP4 (PubMed:22654112).SUBUNIT Interacts with VHL and KAT5 (PubMed:12169691, PubMed:15502158). Does not associate with ING4 or ING5, and does not act as a component of the HBO1 complex (PubMed:19187766).INTERACTION Localizes to the ciliary transition zone.ALTERNATIVE PRODUCTS Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.DOMAIN The 2 PHD-type zinc fingers are required for transcriptional activity.SIMILARITY Belongs to the JADE family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Protein Jade-1 alternativeName: Jade family PHD finger protein 1 alternativeName: PHD finger protein 17 |
| geneName | JADE1 KIAA1807 PHF17 |
| identifier | Q6IE81 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Activator Alternative splicing Apoptosis Cell projection Chromosome Cytoplasm Cytoskeleton Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | JADE1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:2888896] ENSEMBL:ENSG00000077684 JADE1 [Homo sapiens] |
| secondaryIdentifier | JADE1_HUMAN D3DNY0 D3DNY1 Q4W5D5 Q6ZSL7 Q8NC41 Q96JL8 Q96SQ1 Q9H692 |
| sequenceLength | 842 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:233205] UniProt:Q6IE81-2 JADE1 [Homo sapiens] [ReferenceIsoform:233206] UniProt:Q6IE81-3 JADE1 [Homo sapiens] [ReferenceIsoform:408240] UniProt:Q6IE81-1 JADE1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:452931] PHF17 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q6IE81 JADE1 (233204)
