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Details on Person UniProt:Q86U28 ISCA2
| Class:Id | ReferenceGeneProduct:233072 |
|---|---|
| _chainChangeLog | transit peptide:1-8 added on Fri February 6 2015;chain:9-154 added on Fri February 6 2015 |
| _displayName | UniProt:Q86U28 ISCA2 |
| _timestamp | 2025-08-15 22:01:13 |
| chain | transit peptide:1-8 chain:9-154 |
| checksum | D6D16E4451F04625 |
| comment | FUNCTION Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.SUBUNIT Heterotetramer; forms a dimer of dimers with IBA57 (PubMed:31831856). Interacts with [2Fe-2S]-ISCA2 forming the heterodimer [2Fe- 2S]-ISCA2-IBA57 complex; [2Fe-2S] cluster binding is absolutely required to promote the complex formation (PubMed:30269484).INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the HesB/IscA family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Iron-sulfur cluster assembly 2 homolog, mitochondrial alternativeName: HESB-like domain-containing protein 1 |
| geneName | ISCA2 HBLD1 |
| identifier | Q86U28 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Disease variant Iron Iron-sulfur Metal-binding Mitochondrion Primary mitochondrial disease Proteomics identification Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | ISCA2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998373] ENSEMBL:ENSG00000165898 ISCA2 [Homo sapiens] |
| secondaryIdentifier | ISCA2_HUMAN A6NFF1 A8K3W3 G3V291 Q8IYZ0 Q96BB2 |
| sequenceLength | 154 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8971974] UniProt:Q86U28-1 ISCA2 [Homo sapiens] [ReferenceIsoform:8971975] UniProt:Q86U28-2 ISCA2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5691207] ISCA2 [mitochondrial matrix] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q86U28 ISCA2 (233072)
